Stress Response Protein RBM3 Promotes the Development of Colitis-associated Cancer
نویسندگان
چکیده
منابع مشابه
Stress response protein cirp links inflammation and tumorigenesis in colitis-associated cancer.
Colitis-associated cancer (CAC) is caused by chronic intestinal inflammation and is reported to be associated with refractory inflammatory bowel disease (IBD). Defective apoptosis of inflammatory cell populations seems to be a relevant pathogenetic mechanism in refractory IBD. We assessed the involvement of stress response protein cold-inducible RNA-binding protein (Cirp) in the development of ...
متن کاملMolecular and Cellular Pathobiology Stress Response Protein Cirp Links Inflammation and Tumorigenesis in Colitis-Associated Cancer
Colitis-associated cancer (CAC) is caused by chronic intestinal inflammation and is reported to be associated with refractory inflammatory bowel disease (IBD). Defective apoptosis of inflammatory cell populations seems to be a relevant pathogenetic mechanism in refractory IBD. We assessed the involvement of stress response protein cold-inducible RNA-binding protein (Cirp) in the development of ...
متن کاملThe oncoprotein gankyrin promotes the development of colitis-associated cancer through activation of STAT3
Although long-standing colonic inflammation due to refractory inflammatory bowel disease (IBD) promotes the development of colitis-associated cancer (CAC), the molecular mechanisms accounting for the development of CAC remains largely unknown. In this study, we investigated the role of gankyrin in the development of CAC since gankyrin is overexpressed in sporadic colorectal cancers. We analyzed...
متن کاملExpression of stress response protein Grp78 is associated with the development of castration-resistant prostate cancer.
BACKGROUND Induction of molecular chaperone Grp78 (78-kDa glucose-regulated protein) occurs in stress conditions that often characterize tumor microenvironments. We investigated the role of Grp78 in prostate cancer progression and the development of castration resistance, where cancer cells continue to survive despite the stress of an androgen-starved environment. EXPERIMENTAL DESIGN Immunohi...
متن کاملStress-response protein RBM3 attenuates the stem-like properties of prostate cancer cells by interfering with CD44 variant splicing.
Stress-response pathways play an important role in cancer. The cold-inducible RNA-binding protein RBM3 is upregulated in several types of cancer, including prostate cancer, but its pathogenic contributions are undetermined. RBM3 is expressed at low basal levels in human fetal prostate or in CD133(+) prostate epithelial cells (PrEC), compared with the adult prostate or CD133-PrEC, and RBM3 is do...
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ژورنال
عنوان ژورنال: Inflammatory Bowel Diseases
سال: 2017
ISSN: 1078-0998
DOI: 10.1097/mib.0000000000000968